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PhilSPEN Online Journal of Parenteral and Enteral Nutrition

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Submitted Abstracts

PENSA 2017 Congress

Submitted: August 17, 2017

Abstract ID = 49 | Classification: (5) - Enteral Nutrition

Title: EFFECT OF EICOSAPENTAENOIC ACID ON BODY COMPOSITION AND INFLAMMATION MARKERS IN PATIENTS WITH HEAD AND NECK SQUAMOUS CELL CANCER FROM A PUBLIC HOSPITAL IN MEXICO

Author(s): Obed Solís-Martínez, Valentina Plasa-Carvalho, Geraldine Phillips-Sixtos, Yanelly Trujillo-Cabrera, Arturo Hernández-Cuellar, Gloria Eugenia Queipo-García, Eduardo Meaney-Mendiolea, Guillermo M. Ceballos-Reyes, *Vanessa Fuchs-Tarlovsky.

Institution where study was conducted: Hospital General de México. Mexico.

Keywords: Fat/omega-3, omega-6/fish oil, Cachexia, Body mass, Dietary Intervention, Serum markers.

Background: Head and neck cancer patients have important nutritional implications because of the tumor location, swallowing problems or digestive tract obstruction. In addition, anorexia-cachexia syndrome characterized by a degree of chronic inflammation. According to the literature the Eicosapentaenoic acid (EPA) plays an important role in its regulation.

Objectives: To determine the EPA effect on body composition and pro-inflammatory markers in patients with head neck cancer.

Methods: A randomized single-blind, placebo-controlled, clinical trial was conducted in patients with head and neck squamous cell cancer who received a polymeric diet with 2 grams of EPA or a standard polymeric diet for six weeks before antineoplastic treatment. We Body composition was assessed by bioelectrical impedance analysis; IL-1β, IL-6, TNF-α and IFN-γ, CRP, serum proteins and blood count were measured before and after intervention.

Results: 32 patients received EPA (2g/day) and 32 became controls. A decrease in serum levels of IL-1β, IL-6, TNF-α and IFN-γ was observed in the experimental group, as well as regulation of body weight (-0.3±5.9 vs -2.1±3.7), lean body mass (-0.2±3.8 vs -1.3±3.6), body fat mass (0.2±3.5 vs -1.2±3.8) and quality of life (10±33 vs 5±34).

Conclusion: Supplementation with EPA (2g/day) in head and neck cancer patients during antineoplastic treatment regulates serum pro-inflammatory cytokines, body weight, lean body mass, and improve quality of life.

Email: vanessafuchstarlovsky@gmail.com

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