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PhilSPEN Online Journal of Parenteral and Enteral Nutrition

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Submitted Abstracts

PENSA 2017 Congress

Submitted: August 17, 2017

Abstract ID = 50 | Classification: (4) - Disease specific nutrition issues

Title: Effect of antineoplastic treatment on resting energy expenditure and quality of life in patients with gynecological cancer.

Author(s): Vanessa Fuchs-Tarlovsky, Bárbara Torres-Vázquez, Miramontes-Balcón Karina, Carolina Cárcoba-Tenorio, Anahí Raya-Hernández, Lorena Pérez-Moreno, Anaís Romero-Colín, Bejarano-Rosales Mónica Patricia, Alvarez-Altamirano Karolina.

Institution where study was conducted: Department of Clinical Nutrition, Oncology Unit, Hospital General de México.

Keywords: Resting energy expenditure, gynecological cancer, chemotherapy, radiotherapy.

Background: Cancer is a health public problem in world wide. Physiopathology and antineoplastic treatments induce the appearance of signs and symptoms like anorexia, alterations of taste and smell, vomiting and nausea, weight loss, malnutrition in cases of severe cachexia and resting energy expenditure changes associated.

Objectives: To determine the effect of antineoplastic therapy (neoadjuvant chemotherapy and radiotherapy) on Resting Energy expenditure and quality of life in cancer patients.

Methods: A prospective, observational, analytical study was performed on female patients with 18 or more and diagnosis of breast cancer or cervical cancer. Indirect calorimetry measurement was performed before and after antineoplastic treatment, as well as the application of the EORTC QLQ-30 questionnaire to measure quality of life. Statistical analysis was performed by means of descriptive statistics and ANOVA (Analysis of variance) test to determine tests between groups at the end of the study using SPSS version 22.

Results: We assessed 39 female patients: 12 patients in chemotherapy group, 14 in radiotherapy group and 13 in chemo-radiotherapy group. Patients present ovarian or cervical cancer and an average age of 54 years old and body mass index with 29.2 kg/m2. Body weight before treatment decreased (Before treatment: 74.4 kg -After treatment: 66.8 kg) but not showed statistical differences between groups (p=0.059). Regarding energy expenditure total groups average before and after treatment were 1311 ± 386 kcal and 1234 ± 390kcal respectively. Although it was not observed differences between groups at the end of treatment, chemotherapy group (-242.8±436 Kcal) had a higher decrease compared with radiotherapy (+70±216 Kcal) and chemo-radiotherapy (-83±324 Kcal) (p>0.05). Global quality of life not showed differences between groups after antineoplastic treatment (p>0.05).

Conclusion: Resting energy expenditure not show statistical differences at the end of different antineoplastic treatments, however its necessary to select a bigger sample to analyses the results.

Email: vanessafuchstarlovsky@gmail.com

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