PhilSPEN Online Journal of Parenteral and Enteral Nutrition

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(Article 44 | POJ_0039)

Submitted Abstracts

PENSA 2017 Congress

Submitted: June 8, 2017

Abstract ID = 22

Title: Comparing clinical outcome and nutritional status in hypo-caloric vs. full-caloric enteral feeding trauma patients during the first week of hospitalization in intensive care unit

Author(s): Kazemi M.1, Norouzy A.1, Samini F.2, Nematy M.1, Birjandinejad A.2, Mehdizadeh A.1

Institution where study was conducted:

  1. Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. Department of Neurosurgery, Shahid Kamyab Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

University of Medical Sciences, Mashhad, Iran


Background: The appropriate calorie intake for critically ill patients is still a matter of concern in management of patients in Intensive Care Units (ICUs).

Objectives: The purpose of this study was to assess the appropriate amount of energy in ICU admitted trauma patients during the first week of hospitalization to reduce morbidity and mortality.

Methods: A number of 60 adult patients with head trauma was randomly assigned to a double-blind randomized controlled clinical trial. Enteral feeding was administered via identical formula in the first 48 hours of admission to either Full-caloric feeding or Hypo-caloric feeding groups (initiation of energy: 90–100% vs. 40–50% of calculated requirement, respectively). All patients received 100% of required energy until day 7 of intervention and thereafter. Clinical outcomes and metabolic factors were evaluated and compared among groups.

Results: The Full-caloric group patients had significantly more gastrointestinal intolerance (5/2±3 vs. 1/4± 2 days, P<0/001), while Hypo-caloric group showed a better metabolic tolerance and lower liver function enzymes (AST: 55/4±31 vs. 133/7±38 mg/dl, P=0/01 and ALT: 56/1±31 vs. 116/6±72 mg/ dl, P=0/007). The incidence of hyperglycemia (199/5±66 vs 123/3±34 mg/dl, P=0/01), length of hospital stay (35/6±25 vs 19/9±11 days, P=0/03) and days of mechanical ventilation (17/9±21 vs. 4/7±4, P=0/03) were higher in Full-caloric group. There was no statistically significant difference in mortality between groups.

Conclusion: The study suggests that Hypocaloric Enteral feeding is associated with improved metabolic and gastrointestinal tolerance and reduced length of hospital stay and ventilator dependence.


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